B-NDG hB2M/HLA-A11.1 mice plus
| Strain Name |
NOD.CB17-Prkdcscid Il2rgtm1Bcgen Igs2tm1(HLA-A2.1-B2M/HLA-A11.1)Bcgen H2-K1tm1Bcgen H2-D1tm1Bcgen/Bcgen |
Common Name |
B-NDG hB2M/HLA-A11.1 mice plus |
| Background | B-NDG | Catalog number | 112474 |
| Aliases |
IMD43; HLAA |
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Strain specific B2M expression analysis in wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus by flow cytometry. Splenocytes, blood cells and bone marrow were collected from wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus, and analyzed by flow cytometry with species-specific anti-B2M antibody. Mouse B2M was detectable in wild-type mice but not in homozygous B-NDG hB2M/HLA-A11.1 mice plus. Human B2M was exclusively detectable in homozygous B-NDG hB2M/HLA-A11.1 mice plus but not in wild-type mice.
Strain specific HLA-A expression analysis in wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus by flow cytometry. Splenocytes, blood cells and bone marrow were collected from wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus, and analyzed by flow cytometry with species-specific anti-HLA-ABC antibody and anti-H2-K1/H2-D1 antibody. Mouse H2-K1/H2-D1 was detectable in wild-type mice but not in homozygous B-NDG hB2M/HLA-A11.1 mice plus. Human HLA-A was exclusively detectable in homozygous B-NDG hB2M/HLA-A11.1 mice plus but not in wild-type mice.
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